Streptomycin Resistance after Treatment with P.A.S. Alone
نویسندگان
چکیده
منابع مشابه
Effect of para-aminosalicylic acid (PAS) alone and in association with streptomycin on experimental ocular tuberculosis.
THE therapeutic effects of streptomycin and of para-aminosalicylic acid (PAS) in the control of many forms of experimentally induced tuberculosis and in' the treatment of clinical tuberculosis are now well known. Although streptomycin is the most powerful antituberculosis drug which has so far been fully evaluated, evidence is accumulating that a combination of streptomycin and PAS is even more...
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Tuberculosis of the tongue may well be considered a rarity since less than 500 cases have been reported. Statistics vary considerably as to its incidence, but it is probable that the complication would be less rare were more attention given to the tongue upon examination of the patient and at the autopsy table. It is generally agreed that the lingual form of tuberculosis is found less frequentl...
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The earliest workers with penicillin observed that it was extremely effective in vitro against the gonococcus. Florey and his co-workers (Abraham, Chain, Fletcher, Gardner, Heatley, Jennings, and Florey, 1941) found the gonococcus to be the most sensitive of a wide variety of pathogens they tested against penicillin. Clinical experience supported laboratory findings, and penicillin became, and ...
متن کاملStreptomycin resistance in a streptomycin-producing microorganism.
Cell-free extracts of Streptomyces bikiniensis contain an adenosine 5'-triphosphate-dependent kinase which inactivates streptomycin (Sm) and dihydrostreptomycin by phosphorylation. The products have been identified as streptomycin 6-phosphate and dihydrostreptomycin 6-phosphate. Activity was not present in logarithmic-phase cells, which were susceptible to 25 mug of Sm per ml. In stationary-pha...
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Resistance (R) factor-mediated streptomycin (Sm) resistance differs from classical, high-level, chromosome-borne Sm resistance in its dominance over sensitivity and in the level of its effectiveness (in Escherichia coli approximately 25 mug/ml versus >2,000 mug/ml). In addition, an R factor-containing strain, unlike high-level Sm-resistant bacteria, showed an inoculum effect with respect to its...
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ژورنال
عنوان ژورنال: BMJ
سال: 1953
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.4822.1244